Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunosuppressive therapy in polymyositis.

S Currie, J N Walton

    Journal of Neurology, Neurosurgery, and Psychiatry
    |August 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Immunosuppressive drugs showed limited efficacy in treating polymyositis patients, with only two experiencing significant, lasting improvement. The study suggests combination therapy might offer better outcomes for this inflammatory muscle disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Machine learning-based FDG PET-CT radiomics for outcome prediction in larynx and hypopharynx squamous cell carcinoma.

    Clinical radiology·2020
    Same author

    Toxicity and Efficacy of Stereotactic Ablative Body Radiotherapy for Moderately Central Non-small Cell Lung Cancers Using 50 Gy in Five Fractions.

    Clinical oncology (Royal College of Radiologists (Great Britain))·2019
    Same author

    Prediction of outcome in anal squamous cell carcinoma using radiomic feature analysis of pre-treatment FDG PET-CT.

    European journal of nuclear medicine and molecular imaging·2019
    Same author

    Search for the Neutron Decay n→X+γ, Where X is a Dark Matter Particle.

    Physical review letters·2018
    Same author

    How confident are general practitioners in interpreting neuroradiology reports?

    Clinical radiology·2018
    Same author

    Remarks on Tænia, and Treatment by Ethereal Extract of Male Fern in the Abyssinian Expedition.

    Edinburgh medical journal·2018

    Area of Science:

    • Immunology
    • Rheumatology
    • Pharmacology

    Background:

    • Polymyositis is an idiopathic inflammatory myopathy characterized by immune system dysfunction.
    • Previous in-vitro studies indicated disturbed immunological processes in patients with polymyositis.
    • Immunosuppressive drugs are typically reserved for steroid-refractory or intolerant cases.

    Purpose of the Study:

    • To evaluate the efficacy of immunosuppressive drugs in patients diagnosed with polymyositis.
    • To compare treatment responses across different subtypes and associated conditions of polymyositis.

    Main Methods:

    • Seven patients with polymyositis received immunosuppressive drug therapy.
    • In-vitro peripheral blood lymphocyte activity was assessed in five patients prior to treatment.

    Related Experiment Videos

  • Clinical improvement was monitored to assess treatment effectiveness.

    • Main Results:

    • Five out of seven patients showed some degree of improvement.
    • Marked and sustained improvement was observed in only two patients.
    • Optimal response was noted in uncomplicated polymyositis and subacute polymyositis with an unidentified connective tissue disorder.

    Conclusions:

    • Immunosuppressive therapy demonstrated limited efficacy in this small cohort of polymyositis patients.
    • The response to immunosuppressive drugs varied based on the specific subtype and associated conditions of polymyositis.
    • Combined steroid and immunosuppressive therapy may represent a superior initial treatment strategy for polymyositis.