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Relationship between leucocyte and plasma ascorbic acid concentrations.

H S Loh, C W Wilson

    British Medical Journal
    |September 25, 1971
    PubMed
    Summary
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    Ascorbic acid (vitamin C) levels in blood plasma and white blood cells (leukocytes) correlate positively. Leukocyte levels indicate vitamin C storage capacity, while plasma levels reflect metabolic turnover.

    Area of Science:

    • Biochemistry
    • Human Physiology
    • Nutritional Science

    Background:

    • Ascorbic acid (vitamin C) is essential for human health.
    • Understanding the relationship between plasma and leukocyte ascorbic acid is crucial for assessing vitamin C status.
    • Previous studies have explored vitamin C levels in different populations.

    Purpose of the Study:

    • To investigate the correlation between leucocyte and plasma ascorbic acid values in various healthy populations.
    • To determine if vitamin C supplementation affects the relationship between these two measures.
    • To elucidate the roles of leukocyte and plasma ascorbic acid in reflecting vitamin C storage and metabolism.

    Main Methods:

    • Measurement of leucocyte and plasma ascorbic acid in healthy students, adult factory employees, and elderly individuals.

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  • Comparison of ascorbic acid levels in unsupplemented groups versus those receiving daily vitamin C supplementation (500 mg).
  • Statistical analysis of regression lines to assess relationships and differences between groups.

    • Main Results:

    • Significant positive correlations were observed between leucocyte and plasma ascorbic acid in all groups.
    • The relationship differed significantly between supplemented and unsupplemented groups.
    • Leukocyte ascorbic acid showed a limited range in supplemented individuals, indicating saturation, while unsupplemented groups had wider variation.
    • Leukocyte concentrations reflect vitamin C availability for storage, and plasma levels indicate metabolic turnover.

    Conclusions:

    • Leukocyte ascorbic acid can reach saturation levels, suggesting a finite storage capacity.
    • Leukocyte ascorbic acid measurement alone is not a reliable indicator of overall tissue vitamin C status in normal individuals.
    • The combined analysis of plasma and leukocyte ascorbic acid provides insights into vitamin C storage and metabolism.