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Effect of microcirculation changes on brain tissue oxygenation.

H I Bicher, D Bruley, M H Knisely

    The Journal of Physiology
    |September 1, 1971
    PubMed
    Summary
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    Hemorrhage and blood sludging significantly reduce oxygen levels and prolong tissue reoxygenation times in cats. Anti-adhesive drugs can counteract sludging

    Area of Science:

    • Physiology
    • Biomedical Engineering

    Background:

    • Tissue oxygenation is critical for cellular function.
    • Measuring tissue partial pressure of oxygen (P(O) (2)) provides insights into circulatory health.
    • Reoxygenation time is a key indicator of the circulatory system's ability to restore oxygen levels.

    Purpose of the Study:

    • To investigate the impact of hemorrhage and blood sludging on tissue and blood oxygen levels.
    • To evaluate the effect of these conditions on reoxygenation time in feline models.
    • To assess the efficacy of anti-adhesive drugs in mitigating blood sludging effects.

    Main Methods:

    • Utilized a 2 mu tip oxygen micro-electrode and a Beckman oxygen gas analyzer.
    • Measured tissue and blood partial pressure of oxygen (P(O) (2)) in anesthetized cats.

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  • Determined reoxygenation time following anoxic anoxia under various conditions.

    • Main Results:

    • Hemorrhage (15-25 cc/kg) and blood sludging (dextran administration) significantly decreased blood and tissue P(O) (2).
    • Blood sludging markedly prolonged reoxygenation time.
    • Hemorrhage extended reoxygenation time up to fourfold.
    • An anti-adhesive drug counteracted the prolonged reoxygenation time caused by sludging.

    Conclusions:

    • Hemorrhage and blood sludging impair tissue oxygenation.
    • Reoxygenation time is a sensitive parameter for assessing circulatory compromise.
    • Anti-adhesive drugs show potential in managing circulatory issues related to red blood cell aggregation.