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Related Experiment Videos

Laetrile and pregnancy.

R G Peterson, B H Rumack

    Clinical Toxicology
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Laetrile (amygdalin) administration during late pregnancy resulted in a healthy infant. No signs of cyanide toxicity were detected in the newborn, but long-term monitoring is recommended.

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    Area of Science:

    • Obstetrics and Gynecology
    • Pharmacology
    • Toxicology

    Background:

    • Laetrile, also known as amygdalin, is a controversial compound sometimes used as an alternative cancer therapy.
    • Cyanide is a toxic metabolite of laetrile, raising concerns about its safety during pregnancy.
    • Limited data exists on the effects of laetrile exposure on fetal development and neonatal outcomes.

    Purpose of the Study:

    • To evaluate the safety of laetrile (amygdalin) administered during the third trimester of pregnancy.
    • To assess for evidence of cyanide or thiocyanate toxicity in a neonate exposed to laetrile in utero.

    Main Methods:

    • Case report of a pregnancy with maternal laetrile administration via intramuscular injections during the last trimester.
    • Laboratory and clinical assessments for cyanide and thiocyanate levels in the neonate.

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  • Neurological evaluation of the infant.

    • Main Results:

    • A live, full-term infant was delivered without apparent complications.
    • No laboratory or clinical evidence of elevated cyanide or its principal metabolite, thiocyanate, was detected in the infant.
    • Potential for unrecognized neurological effects of chronic cyanide exposure in infancy cannot be ruled out.

    Conclusions:

    • Intramuscular laetrile administration in the third trimester of pregnancy may not result in detectable cyanide toxicity in the neonate.
    • Long-term neurological follow-up of infants exposed to laetrile during pregnancy is warranted due to the potential for delayed or subtle adverse effects.