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Injected progestogen and lactation.

M Karim, R Ammar, S el-Mahgoub

    British Medical Journal
    |January 23, 1971
    PubMed
    Summary
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    Long-acting injectable contraceptives, norethisterone enanthate and medroxyprogesterone acetate, are effective for postpartum fertility control. These hormonal methods did not negatively impact breastfeeding or milk production, showing potential benefits for infant weight gain.

    Area of Science:

    • Reproductive Endocrinology
    • Lactation Physiology
    • Contraception

    Background:

    • Postpartum women require effective and safe contraception methods.
    • Hormonal contraceptives are widely used but concerns exist regarding their impact on lactation.
    • Long-acting injectable progestogens are a potential option for postpartum contraception.

    Purpose of the Study:

    • To evaluate the efficacy of norethisterone enanthate and medroxyprogesterone acetate for postpartum fertility control.
    • To assess the impact of these agents on milk production and lactation duration.
    • To monitor infant growth and identify any significant side effects.

    Main Methods:

    • Prospective study comparing injectable contraceptives with a control group.
    • Norethisterone enanthate (200 mg every 84 days) and medroxyprogesterone acetate (150 mg every three months) administered postpartum.

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  • Monitoring of milk availability, lactation duration, infant weight gain, and maternal side effects.
  • Main Results:

    • Both norethisterone enanthate and medroxyprogesterone acetate demonstrated complete effectiveness in preventing pregnancy.
    • No adverse effects on milk volume or lactation duration were observed; higher milk availability and infant weight gain noted in treated groups from month three.
    • A slight decrease in milk protein was observed across groups, attributed to dietary factors. Amenorrhea was the primary noted side effect.

    Conclusions:

    • Long-acting injectable progestogens are highly effective for postpartum contraception.
    • These agents do not compromise breastfeeding and may enhance infant growth.
    • Amenorrhea is a common, non-serious side effect, with no other significant adverse events reported.