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Related Experiment Videos

Penicillin hypersensitivity in systemic lupus erythematosus.

K von Maur, A Turk, M B Stevens

    International Archives of Allergy and Applied Immunology
    |January 1, 1975
    PubMed
    Summary

    Patients with systemic lupus erythematosus (SLE) do not have more immediate allergic reactions to penicillin, despite higher reported histories of reactions. Skin tests showed no increased risk for IgE-mediated penicillin allergies in SLE patients.

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    Area of Science:

    • Immunology
    • Rheumatology
    • Allergy

    Background:

    • Systemic lupus erythematosus (SLE) is an autoimmune disease.
    • Patients with SLE often report adverse reactions to medications, including penicillin.
    • The risk of IgE-mediated penicillin allergy in SLE patients is not well-established.

    Purpose of the Study:

    • To investigate the prevalence of positive immediate-type skin tests to penicillin antigens in patients with SLE.
    • To compare penicillin skin test reactivity between SLE patients and non-SLE controls.
    • To determine if SLE patients have an increased risk of IgE-mediated allergic reactions to penicillin.

    Main Methods:

    • Comparison of immediate-type skin test results to penicillin antigens between SLE patients and hospitalized controls without SLE.

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  • Analysis of the prevalence of reported histories of prior penicillin reactions in both groups.

    • Main Results:

    • No significant difference in positive immediate-type skin tests to penicillin antigens was observed between SLE patients and controls.
    • A significantly higher prevalence of reported histories of prior penicillin reactions was found in SLE patients compared to controls.
    • The observed higher rate of reported reactions in SLE patients is attributed to the primary disease process.

    Conclusions:

    • Patients with SLE do not exhibit an increased risk for IgE-mediated allergic reactions to penicillin.
    • Reported penicillin reactions in SLE patients may be associated with the underlying autoimmune condition rather than true allergy.
    • Further research may be warranted to differentiate reported reactions from true allergic responses in SLE patients.