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Related Experiment Videos

The structure of synaptosomal plasma membrane.

A P Smith, H H Loh

    Drug and Alcohol Dependence
    |January 1, 1979
    PubMed
    Summary

    Synaptosomal plasma membrane (SPM) structure aligns with the fluid mosaic model. SPM exhibits significant asymmetry in protein distribution, with most proteins located externally and maintained by junctional immobilization.

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    Area of Science:

    • Neuroscience
    • Cell Biology
    • Biochemistry

    Background:

    • Plasma membranes, including synaptosomal plasma membrane (SPM), are composed of lipids and proteins.
    • The fluid mosaic model describes membrane structure as dynamic and fluid.

    Purpose of the Study:

    • To elucidate the structural organization and component distribution within the synaptosomal plasma membrane (SPM).
    • To investigate the asymmetry and lateral distribution of proteins in SPM.

    Main Methods:

    • Analysis of synaptosomal plasma membrane (SPM) composition.
    • Application of the fluid mosaic model to SPM structure.

    Main Results:

    • SPM components conform to the fluid mosaic model.
    • A marked asymmetry in the inside-outside distribution of SPM components was observed, with most proteins external.
    • Lateral protein distribution is asymmetric, stabilized by immobilization at junctions.

    Conclusions:

    • Synaptosomal plasma membrane (SPM) exhibits structural and compositional asymmetry consistent with the fluid mosaic model.
    • Protein localization and immobilization play critical roles in maintaining SPM organization and function.

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