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Related Experiment Videos

Intercellular matrix in colonies of Candida.

K R Joshi, J B Gavin, L C Armiger

    Journal of Bacteriology
    |September 1, 1975
    PubMed
    Summary

    This study reveals Candida colonies comprise viable and degenerate cells within an intercellular matrix. The matrix composition and structure vary by species, influencing colony morphology and surface features.

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    Area of Science:

    • Mycology
    • Cell Biology
    • Biochemistry

    Background:

    • Candida species are opportunistic fungal pathogens.
    • Understanding Candida colony structure is crucial for antifungal strategies.
    • Previous studies have not fully detailed the intercellular matrix composition.

    Purpose of the Study:

    • To investigate the histochemistry and fine structure of Candida colonies.
    • To characterize the intercellular matrix and its components.
    • To compare matrix variations across six Candida species.

    Main Methods:

    • Histochemical staining techniques.
    • Transmission electron microscopy (TEM) for fine structure analysis.
    • Examination of 31 clinical isolates from six Candida species.

    Main Results:

    • Candida colonies contain viable and degenerate cells embedded in an intercellular matrix.
    • The matrix consists of amorphous, granular, and fibrillar components, varying by species.
    • A homogeneous amorphous layer surrounds cells, potentially a cross-linked carbohydrate, separating them from cellular debris.
    • C. albicans and C. tropicalis exhibit extensive matrix, forming a surface coat and prominent fibrillar meshwork.

    Conclusions:

    • Intercellular matrix composition and structure are key differentiating features of Candida species colonies.
    • The matrix plays a role in colony architecture and surface properties.
    • Species-specific matrix variations may influence interactions with host environments and antifungal treatments.

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