Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intestinal secretion: stimulation by peptides.

G O Barbezat, M I Grossman

    Science (New York, N.Y.)
    |October 22, 1971
    PubMed
    Summary

    Vasoactive intestinal peptide and gastric inhibitory peptide stimulate intestinal secretion. Other peptides like glucagon and pentagastrin also stimulate, but secretin and octapetide of cholecystokinin do not, suggesting a role in regulating intestinal fluid balance.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Diagnosis of helicobacter pylori infection by polymerase chain reaction: is it worth it?

    Diagnostic microbiology and infectious disease·2004
    Same author

    Somatostatin enhances cAMP-dependent short-circuit current in human colon via somatostatin receptor subtype-2.

    Digestive diseases and sciences·2001
    Same author

    New treatment for Barrett's oesophagus.

    Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2000
    Same author

    Omeprazole therapy decreases the need for dilatation of peptic oesophageal strictures.

    Alimentary pharmacology & therapeutics·1999
    Same author

    Facts and fables in management of Helicobacter pylori.

    The Medical journal of Australia·1999
    Same author

    Choleresis induced by stimulation of the gastric antrum.

    Journal of laparoendoscopic & advanced surgical techniques. Part A·1999

    Area of Science:

    • Gastroenterology
    • Endocrinology
    • Physiology

    Background:

    • Intestinal secretion is crucial for nutrient absorption and waste elimination.
    • Peptides play significant roles in regulating gastrointestinal functions.
    • Dysregulation of intestinal secretion is implicated in various gastrointestinal disorders.

    Purpose of the Study:

    • To investigate the effects of specific intestinal peptides on small intestinal secretion.
    • To identify which peptides stimulate or inhibit intestinal fluid secretion.
    • To explore the potential role of these peptides in the regulation of intestinal secretion.

    Main Methods:

    • Experiments conducted on conscious dogs.
    • Administration of isolated intestinal peptides, including vasoactive intestinal peptide (VIP) and gastric inhibitory peptide (GIP).
    • Measurement of small intestinal secretion in response to peptide administration.

    Main Results:

    • Vasoactive intestinal peptide (VIP) and gastric inhibitory peptide (GIP) were found to stimulate small intestinal secretion.
    • Glucagon and pentagastrin also demonstrated stimulatory effects on intestinal secretion.
    • Secretin and the octapetide of cholecystokinin did not stimulate intestinal secretion.

    Conclusions:

    • Certain peptides, notably VIP and GIP, are potent stimulators of intestinal secretion.
    • These findings suggest a role for these peptides in the physiological regulation of intestinal secretion.
    • Understanding these mechanisms could be relevant for managing conditions with excessive intestinal secretion.

    Related Experiment Videos