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[Serum and tissue concentrations after a single dose of cefaclor]
Infection
|January 1, 1979
Summary
Cefaclor penetrates various human tissues after a 1g dose, with highest concentrations in serum. This antibiotic is minimally present in fascia and skin, and undetectable in cortical bone.
Area of Science:
- Pharmacokinetics
- Antibiotic distribution
- Human tissue analysis
Context:
- Understanding cefaclor's distribution is crucial for optimizing antibiotic therapy.
- Previous studies have not fully elucidated cefaclor penetration into diverse human tissues.
- This research investigates cefaclor concentrations in serum and multiple tissue types.
Purpose:
- To quantify serum and tissue concentrations of cefaclor following a single oral dose.
- To differentiate between intravascular and extravascular cefaclor components in various tissues.
- To determine cefaclor's presence in cortical bone, spongy bone, muscle, fascia, cutis, and subcutis.
Summary:
- Serum and tissue concentrations of cefaclor were measured in 16 volunteers after a 1g dose.
- Peak serum concentrations ranged from 13.4 to 14.5 mcg/ml between 60-120 minutes.
- Cefaclor was found in low extravascular amounts in fascia and cutis; concentrations in spongy bone, muscle, and subcutis were largely intravascular. No cefaclor was detected in cortical bone.
Impact:
- Provides essential pharmacokinetic data on cefaclor distribution in human tissues.
- Informs clinical decisions regarding cefaclor efficacy in various infection sites.
- Highlights limitations of cefaclor penetration into bone tissue at the tested dosage.