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Related Experiment Videos

Intercellular adhesion as a function of the cell cycle traverse.

C G Hellerqvist

    The Journal of Cell Biology
    |September 1, 1979
    PubMed
    Summary
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    Cell adhesion rates vary throughout the cell cycle. Cells in G1 phase exhibit significantly higher intercellular adhesion compared to S phase cells, indicating cell cycle-dependent changes in adhesion molecules.

    Area of Science:

    • Cell Biology
    • Biochemistry

    Background:

    • Intercellular adhesion is crucial for cellular functions.
    • Understanding cell adhesion dynamics is key to comprehending biological processes.

    Purpose of the Study:

    • To investigate the relationship between cell cycle progression and intercellular adhesion rates.
    • To identify cell cycle-specific changes in cellular adhesiveness.

    Main Methods:

    • Utilized synchronized Chinese Hamster Ovary-K1 cells in a monolayer assay.
    • Quantified intercellular adhesion rates across different cell cycle phases (G1 and S).

    Main Results:

    • Cells in G1 phase demonstrated twice the adhesion rate compared to S phase cells.
    • Adhesion between G1 and S phase cells occurred at an intermediate rate.

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  • Trypsinization abolished the increased adhesiveness observed in G1 cells.

    • Conclusions:

    • Intercellular adhesion is significantly influenced by the cell cycle stage.
    • A qualitative or quantitative alteration in adhesion components occurs during the G1 phase.
    • These findings suggest cell cycle-dependent regulation of cell adhesion mechanisms.