Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Binding of DDT to lecithin.

I J Tinsley, R Haque, D Schmedding

    Science (New York, N.Y.)
    |October 8, 1971
    PubMed
    Summary

    DDT and lecithin interact, affecting each other's proton magnetic resonance spectra. This interaction involves lecithin's phosphoryl choline and DDT's benzylic proton, with a calculated equilibrium constant.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Interconnected pathways link faecal microbiota plasma lipids and brain activity to childhood malnutrition related cognition.

    Nature communications·2025
    Same author

    Response to Letter to Editor: Comment on "The infant gut microbiome and cognitive development in malnutrition".

    Clinical nutrition (Edinburgh, Scotland)·2024
    Same author

    UNITY: A low-field magnetic resonance neuroimaging initiative to characterize neurodevelopment in low and middle-income settings.

    Developmental cognitive neuroscience·2024
    Same author

    Achievement of Target Gain Larger than Unity in an Inertial Fusion Experiment.

    Physical review letters·2024
    Same author

    Vulnerable newborn types: analysis of subnational, population-based birth cohorts for 541 285 live births in 23 countries, 2000-2021.

    BJOG : an international journal of obstetrics and gynaecology·2023
    Same author

    Thermodynamic Analysis of a Flat Plate Solar Collector with Different Hybrid Nanofluids as Working Medium-A Thermal Modelling Approach.

    Nanomaterials (Basel, Switzerland)·2023

    Area of Science:

    • Analytical Chemistry
    • Biochemistry
    • Environmental Science

    Background:

    • DDT (Dichlorodiphenyltrichloroethane) is a persistent organic pollutant with known environmental and health impacts.
    • Lecithin, a phospholipid, is a crucial component of biological membranes and plays various physiological roles.
    • Understanding molecular interactions is vital for assessing the behavior and effects of environmental contaminants.

    Purpose of the Study:

    • To investigate the molecular interaction between DDT and lecithin.
    • To elucidate the specific chemical moieties involved in this interaction.
    • To quantify the binding affinity between DDT and lecithin.

    Main Methods:

    • Proton magnetic resonance (PMR) spectroscopy was employed to monitor spectral changes.
    • Varying concentrations of DDT and lecithin were used to observe reciprocal effects.
    • Chemical shifts of specific proton resonances were analyzed to identify interaction sites.

    Main Results:

    • Reciprocal changes in the PMR spectra of DDT and lecithin indicated a molecular interaction.
    • The phosphoryl choline group of lecithin and the benzylic proton of DDT were identified as key interaction sites.
    • An equilibrium constant of 0.597 ± 0.015 molal⁻¹ was determined for the DDT-lecithin interaction.

    Conclusions:

    • DDT and lecithin form a complex, primarily involving lecithin's choline methyl groups and DDT's benzylic/ring protons.
    • The quantitative data provides insight into the binding strength and nature of this interaction.
    • Findings contribute to understanding DDT's environmental fate and potential interactions with biological lipids.

    Related Experiment Videos