Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pituitary adenomas. Clinico-morphologic correlations.

A M Landolt

    The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society
    |October 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    [Palliative treatment of brain metastases with gamma knife].

    Therapeutische Umschau. Revue therapeutique·2001
    Same author

    History of pituitary surgery from the technical aspect.

    Neurosurgery clinics of North America·2001
    Same author

    Gamma knife radiosurgery for prolactinomas.

    Journal of neurosurgery·2001
    Same author

    Development of pituitary adenoma treatment--a critical essay.

    Pituitary·2000
    Same author

    Octreotide may act as a radioprotective agent in acromegaly.

    The Journal of clinical endocrinology and metabolism·2000
    Same author

    17Beta-hydroxysteroid dehydrogenase type 1, 2, 3, and 4 expression and enzyme activity in human anterior pituitary adenomas.

    The Journal of clinical endocrinology and metabolism·1999
    Same journal

    Expression and Spatial Localization of Glycosaminoglycan Types in Cartilage From Different Anatomical Locations.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    Aquaporin-4 Localization in Terminal Glial Cells of Human Mechanosensory Corpuscles: An Immunohistochemical Study of Penile Tissues.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    Seeing, Interpreting, and Trusting Images in the Age of Artificial Intelligence.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    P63 and Tight Junctions Targeted for Therapy in Human Salivary Duct Adenocarcinoma Cells.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    Human iPSC-Derived Blood Vessel Organoids for Studying Chronic Hypoxia-Induced Microvascular Dysfunction.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    Same journal

    From Manual to Macro: A Reproducible Fiji Workflow for Semi-automated Collagen Fibril Diameter Quantification in Transmission Electron Microscopy.

    The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society·2026
    See all related articles

    New insights into pituitary gland biology reveal hyperplasia can precede adenoma formation. Adenomas exhibit varying degrees of independence from hypothalamic control and hormonal activity.

    Area of Science:

    • Endocrinology
    • Cell Biology
    • Pathology

    Background:

    • The hypophysis (pituitary gland) plays a crucial role in hormonal regulation.
    • Proliferative processes within the hypophysis, such as hyperplasia and adenoma formation, require detailed biological understanding.
    • Hypothalamic factors are known regulators of pituitary function and growth.

    Purpose of the Study:

    • To elucidate the biological and natural history of hypophyseal proliferative processes.
    • To differentiate between pituitary hyperplasia and adenoma development.
    • To investigate the regulatory mechanisms, including hypothalamic control, over these conditions.

    Main Methods:

    • Utilizing immunohistochemistry for cellular and molecular analysis.
    • Employing electron microscopy for ultrastructural examination.

    Related Experiment Videos

  • Correlating histological findings with functional and regulatory aspects.

    • Main Results:

    • Pituitary hyperplasia can manifest as diffuse or focal changes.
    • Hyperplasia is typically regulated by hypothalamic factors and may precede adenoma formation.
    • Pituitary adenomas demonstrate partial to complete independence from hypothalamic regulation.
    • Adenomas are classified by functional activity (active vs. inactive) and hormone secretion profile.
    • Inactive adenomas may exhibit hormone production loss, low-rate secretion, or abnormal substance secretion.

    Conclusions:

    • Immunohistochemistry and electron microscopy provide critical insights into hypophyseal proliferative disorders.
    • Understanding the transition from hyperplasia to adenoma is key to comprehending pituitary tumorigenesis.
    • Pituitary adenoma autonomy from hypothalamic control is a significant characteristic.
    • Classification based on hormonal activity and secretion is essential for understanding adenoma behavior.