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Appendicitis and mimicking conditions. A prospective study.

O J Gilmore, J P Browett, P H Griffin

    Lancet (London, England)
    |September 6, 1975
    PubMed
    Summary
    This summary is machine-generated.

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    This study on acute appendicitis found a 22% diagnostic error rate, which was higher in females. Organisms were frequently isolated from inflamed appendix walls, indicating infection is common in appendicitis.

    Area of Science:

    • Surgery
    • Gastroenterology
    • Infectious Diseases

    Background:

    • Acute appendicitis is a common surgical emergency.
    • Accurate diagnosis is crucial for timely intervention and preventing complications.
    • Diagnostic challenges exist, particularly in specific patient demographics.

    Purpose of the Study:

    • To evaluate the diagnostic accuracy and clinical findings in patients with suspected acute appendicitis.
    • To identify factors contributing to diagnostic errors.
    • To analyze the microbiological findings and associated pathologies.

    Main Methods:

    • Prospective study of 444 consecutive patients with suspected acute appendicitis.
    • Surgical exploration and pathological examination of the appendix.

    Related Experiment Videos

  • Microbiological cultures from the appendix wall.
  • Analysis of patient demographics and co-existing conditions.

    • Main Results:

    • Overall diagnostic error rate was 22%, twice as common in females.
    • 346 patients (78%) had inflamed, gangrenous, or perforated appendix.
    • Organisms isolated from 117 patients, increasing with inflammation severity.
    • Associated conditions included mesenteric adenitis (12% in children <11), gynecological lesions (10% in females), and diverticulitis (14% in patients >50).
    • No abnormality found in only 6% of patients.

    Conclusions:

    • Diagnostic errors in acute appendicitis are significant, particularly in females.
    • Microbial presence correlates with appendicitis severity.
    • Non-appendiceal pathologies should be considered in differential diagnosis.
    • Gridiron incision is an effective surgical approach for appendicitis.