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Trophic muscle regulation in children with congenital cerebral lesions
Insights
Children with congenital cerebral lesions may experience reduced sarcomere number and ankle extensor hypoextensibility. Muscle adaptation, indicated by torque-ankle angle curve changes, occurred in some, but not all, patients, suggesting absent trophic regulation in certain cases.
Area of Science:
- Neurology
- Muscle Physiology
- Pediatrics
Background:
- Congenital cerebral lesions can impact muscle properties.
- Sarcomere number and muscle extensibility are key indicators of muscle health.
- Trophic regulation plays a role in muscle adaptation to length changes.
Purpose of the Study:
- To investigate muscle adaptation in children with congenital cerebral lesions.
- To analyze the torque-angle curve as a measure of muscle adaptation.
- To identify factors influencing muscle adaptation and trophic regulation.
Main Methods:
- Studied 30 children with congenital cerebral lesions.
- Analyzed the torque-ankle angle curve to assess muscle properties.
- Observed changes in the curve after treatment to evaluate adaptation.
Main Results:
- Decreased sarcomere number and hypoextensibility were noted in some children.
- Muscle adaptation, shown by torque-angle curve modification, was present in 14 children.
- Treatment efficacy varied, with some children showing no curve modification, indicating absent trophic regulation.
Conclusions:
- Muscle adaptation to imposed length changes is possible in children with cerebral lesions.
- The torque-ankle angle curve is a useful tool for assessing muscle adaptation.
- Absence of trophic regulation may explain treatment failure in some cases.
Abstract:
A decrease in sarcomere number and hypoextensibility of ankle extensors was observed in certain children with congenital cerebral lesions. This phenomenon was reproducible and reversible in normal animals, i.e. trophic regulation adapted the muscle to the imposed length. The form of the torque-ankle angle curve was studied in 30 children. Its modification after treatment was considered as a sign of muscle adaptation. This adaptation was present in one group of 14 children. The steepness of the curve increased or diminished depending on the initial disorder and the treatment administered. In another group, treatment failed to modify the shape of the curve. In certain cases trophic regulation of the muscle appeared to be absent.