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Related Experiment Videos

Thyrotoxic myopathy: a clinical and quantitative analytic electromyographic study.

K Puvanendran, J S Cheah, N Naganathan

    Journal of the Neurological Sciences
    |August 1, 1979
    PubMed
    Summary

    Thyrotoxicosis frequently causes subclinical myopathy, detectable by electromyography, even when muscle weakness is not apparent. This study found electromyographic muscle changes in all thyrotoxic patients, highlighting the prevalence of thyrotoxic myopathy.

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    Area of Science:

    • Endocrinology
    • Neurology
    • Clinical Electrophysiology

    Background:

    • Chronic thyrotoxic myopathy was historically considered rare.
    • Thyrotoxicosis is a condition resulting from excessive thyroid hormone production.
    • Muscle involvement is a known complication of hyperthyroidism.

    Purpose of the Study:

    • To investigate the prevalence and characteristics of muscle involvement in patients with thyrotoxicosis.
    • To compare clinical assessment of muscle strength with electromyographic findings in thyrotoxicosis.
    • To determine if electromyography can detect myopathy in thyrotoxicosis patients without overt clinical symptoms.

    Main Methods:

    • Studied 48 consecutive patients diagnosed with thyrotoxicosis.
    • Utilized clinical examinations to assess for muscle weakness and/or atrophy.

    Related Experiment Videos

  • Employed quantitative electromyography (EMG) to analyze muscle electrical activity at standard tension and minimal effort.
  • Quantified EMG interference patterns using numerical parameters like potential changes per second and mean amplitude.

    • Main Results:

    • All patients with confirmed thyrotoxicosis (clinical and biochemical) exhibited electromyographic signs of myopathy.
    • Overt clinical myopathy, characterized by muscle weakness and/or atrophy, was present in 68% of the patients.
    • Electromyography revealed subclinical myopathy in 32% of thyrotoxicosis patients who did not present with clinical muscle symptoms.

    Conclusions:

    • Thyrotoxicosis is associated with a high prevalence of myopathy, often subclinical.
    • Electromyography is a sensitive tool for detecting muscle involvement in thyrotoxicosis, even in the absence of clinical signs.
    • The findings suggest that thyrotoxic myopathy is more common than previously recognized and electromyography should be considered in the assessment of thyrotoxic patients.