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Lymphocyte response depressive factor in multiple sclerosis.

E J Field, E A Caspary

    British Medical Journal
    |November 27, 1971
    PubMed
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    Normal serum has a unique factor that suppresses lymphocyte response, acting like a "tailor-made" brake. This suppressor factor is elevated in neurological diseases, suggesting a role in disease pathogenesis.

    Area of Science:

    • Immunology
    • Neuroscience

    Background:

    • Normal serum contains a factor that suppresses lymphocyte responses.
    • This factor exhibits higher activity against autologous lymphocytes compared to allogeneic ones, indicating a 'tailor-made' specificity.

    Purpose of the Study:

    • To investigate the nature and significance of the lymphocyte response depressive factor.
    • To compare the levels of this suppressor factor in normal individuals versus patients with destructive neurological diseases.

    Main Methods:

    • Serum analysis to identify and quantify the lymphocyte response depressive factor.
    • Comparative studies of factor activity against autologous and allogeneic lymphocytes.
    • Titre determination in serum samples from healthy controls and patients with multiple sclerosis and other neurological disorders.

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    Main Results:

    • The lymphocyte response depressive factor is more active against autologous lymphocytes, demonstrating 'tailor-made' specificity with some cross-reactivity.
    • Serum from patients with multiple sclerosis and other destructive neurological diseases shows a higher titre of this suppressor factor compared to normal serum.

    Conclusions:

    • The findings suggest an 'accelerator-brake' mechanism regulating lymphocyte responses, where the suppressor factor acts as a brake.
    • Elevated suppressor factor levels in neurological diseases may indicate an imbalance in this regulatory mechanism, potentially contributing to pathogenesis.
    • Therapeutic manipulation of suppressor substance levels could be a future treatment strategy for such diseases.