Related Experiment Video

Updated: Aug 18, 2026

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
09:45

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

Synthesis of new mercaptotriazoles with potential antibilharzial activity

R Soliman, N A Hammouda

    Journal of Pharmaceutical Sciences
    |November 1, 1979
    PubMed

    Abstract:

    Several 3-mercaptotriazoles with the 8-hydroxyquinoline moiety in the 5-position were prepared and tested for antiparasitic activity. Preliminary biological tests on experimentally infected mice with Schistosoma mansoni worms revealed that the new compounds possess potent schistosomicidal activity.

    More Related Videos

    Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
    10:42

    Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

    Published on: January 3, 2018

    Production and Testing of Antimicrobial Peptides and Their Mimics
    10:35

    Production and Testing of Antimicrobial Peptides and Their Mimics

    Published on: April 10, 2026

    Related Experiment Videos

    Last Updated: Aug 18, 2026

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
    09:45

    Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

    Published on: April 27, 2017

    Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines
    10:42

    Preparation of N-(2-alkoxyvinyl)sulfonamides from N-tosyl-1,2,3-triazoles and Subsequent Conversion to Substituted Phthalans and Phenethylamines

    Published on: January 3, 2018

    Production and Testing of Antimicrobial Peptides and Their Mimics
    10:35

    Production and Testing of Antimicrobial Peptides and Their Mimics

    Published on: April 10, 2026

    Related Concept Videos

    Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation01:22

    Phase II Reactions: Glutathione Conjugation and Mercapturic Acid Formation

    Glutathione, a tripeptide made up of glutamate, cysteine, and glycine, is a critical player in the detoxification of drugs and xenobiotics via a process known as glutathione conjugation or mercapturic acid formation. This phase II biotransformation reaction involves the covalent binding of glutathione to a drug or its metabolite, enhancing the compound's water solubility and enabling its excretion.
    Several distinctive characteristics distinguish glutathione conjugation from other phase II...
    Antiprotozoal Agents01:21

    Antiprotozoal Agents

    Leishmaniasis is a widespread parasitic disease caused by several Leishmania species. It affects millions of people each year and remains a major public health problem in endemic regions. First-line treatment relies on pentavalent antimonials, including meglumine antimoniate and sodium stibogluconate. Even so, how these drugs work has not been fully clear, especially their interaction with parasite-specific biochemical pathways. One key target is trypanothione reductase (TR), an enzyme that...

    Articles linked to this work by shared authors, journal, and citation graph.

    Development, preparation, and evaluation of a novel non-adjuvanted polyvalent dermatophytes vaccine.

    Scientific reports·2023

    Sofosbuvir plus Daclatasvir with or without ribavirin for treatment of chronic HCV genotype 4 patients: real-life experience.

    Hepatology international·2018

    A simple bedside blood test (Fibrofast; FIB-5) is superior to FIB-4 index for the differentiation between non-significant and significant fibrosis in patients with chronic hepatitis C.

    Hepatology international·2017

    Molecular and epidemiological analysis of methicillin-resistant Staphylococcus aureus otorrhoea: hospital- or community-acquired?

    The Journal of laryngology and otology·2010

    Pyrimidines. Part II: Synthesis of novel pyrimidines, 1,2,4-triazolo[4,3-a]pyrimidin-7-ones and pyrimidino[2,1-c][1,2,4]triazin-8-ones for their antimicrobial and anticancer activities.

    Bollettino chimico farmaceutico·2004

    Synthesis of novel pyrimidine-2,4-diones and 2-thioxo-pyrimidine-4-ones as potential anticancer and antimicrobial agents.

    Bollettino chimico farmaceutico·2003

    The shake-test for adjuvanted vaccines: A manufacturer's perspective.

    Journal of pharmaceutical sciences·2026

    Development of novel pH-responsive liposomes composed of anionic lipids and pH-sensitive cationic lipids for efficient drug release in weakly acidic environments.

    Journal of pharmaceutical sciences·2026

    At-line estimation of powder lubrication using rotating drum: Linking specific volume kinetics to tensile strength loss.

    Journal of pharmaceutical sciences·2026

    Intranasal delivery of sertraline hydrochloride enhanced brain concentration and antidepressant activity: A comparative pharmacokinetic and pharmacodynamic study.

    Journal of pharmaceutical sciences·2026

    A novel approach to unified compaction curve model for improved tabletability prediction of virtual roller compacted formulations.

    Journal of pharmaceutical sciences·2026

    Physiologically based pharmacokinetic modeling for methotrexate in cerebrospinal fluid in humans.

    Journal of pharmaceutical sciences·2026

    MolSelector: A Machine Learning Framework for Interpretable Subset Selection from Molecular Science Data Sets.

    Journal of chemical information and modeling·2026

    Probe-Atom Distributions Obtained from Mixed-Solvent Molecular Dynamics Improve the Scoring of Docking Calculations.

    Journal of chemical information and modeling·2026

    Multiscale Free-Energy Methods for Protonation-Coupled Light-Responsive Binding of Ionizable Photoswitchable eDHFR Inhibitors.

    Journal of chemical information and modeling·2026

    MolADR: Multi-Scale Complementary Learning of Dual-Granularity Molecules and Knowledge Graphs for ADR Prediction in Drug Combinations.

    Journal of chemical information and modeling·2026

    Ensemble-Based Reconstruction and Prioritization of Binding Sites in Influenza A Nucleoprotein.

    Journal of chemical information and modeling·2026

    Mutation-Guided Recovery of Ligand-Compatible Holo-Like Conformations in Proteins with Cryptic Pockets.

    Journal of chemical information and modeling·2026
    See all related articles
    JoVE
    x logofacebook logolinkedin logoyoutube logo
    ABOUT JoVE
    OverviewLeadershipBlogJoVE Help Center
    AUTHORS
    Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
    LIBRARIANS
    TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
    RESEARCH
    JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
    EDUCATION
    JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
    Terms & Conditions of Use
    Privacy Policy
    Policies
    Jove
    Visualize
    Contact Us