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Related Experiment Videos

The sickle-cell and altitude.

R L Green, R G Huntsman, G R Serjeant

    British Medical Journal
    |December 4, 1971
    PubMed
    Summary
    This summary is machine-generated.

    High altitude poses risks for individuals with sickle-cell trait and sickle-cell haemoglobin C disease during air travel. Patients with sickle-cell anaemia may tolerate pressurized flights, but screening is advised for all air travelers and crew.

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    Area of Science:

    • Hematology
    • Aerospace Medicine
    • Public Health

    Background:

    • Sickle-cell disease encompasses several genetic blood disorders.
    • High altitude environments can precipitate health crises in susceptible individuals.
    • Air travel presents unique physiological challenges, including altered atmospheric pressure.

    Purpose of the Study:

    • To investigate the association between high altitude and sickle cell crises.
    • To assess the risks of air travel for individuals with different forms of sickle-cell disease.
    • To provide recommendations for safe air travel concerning sickle-cell disorders.

    Main Methods:

    • Case review of recent sickle cell crises linked to high altitude exposure.
    • Analysis of risks associated with unpressurized and pressurized aircraft.

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  • Evaluation of physiological tolerance to air travel based on sickle-cell genotype.

    • Main Results:

    • Seven cases of sickling crisis were potentially linked to high altitude.
    • Individuals with sickle-cell trait are at risk in unpressurized aircraft.
    • Sickle-cell haemoglobin C disease patients should avoid all air travel; sickle-cell anaemia patients may tolerate pressurized flights.

    Conclusions:

    • High altitude is a significant risk factor for sickle cell crises.
    • Differential risks exist for various sickle-cell conditions during air travel.
    • Pre-flight screening for sickle-cell disease in passengers and aircrew is recommended.