Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Aberrant visual projections in the Siamese cat.

D H Hubel, T N Wiesel

    The Journal of Physiology
    |October 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Siamese cats exhibit abnormal visual pathways, with fibers crossing incorrectly and impacting the lateral geniculate body and visual cortex. This study investigates the physiological consequences of this aberrant projection in Siamese cats.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Republication of The Journal of Physiology (1959) 148, 574-591: Receptive fields of single neurones in the cat's striate cortex. 1959.

    The Journal of physiology·2009
    Same author

    Nobel laureates' letter to President Bush.

    The Washington post·2002
    Same author

    Microsaccadic eye movements and firing of single cells in the striate cortex of macaque monkeys.

    Nature neuroscience·2000
    Same author

    Early explorations of the development and plasticity of the visual cortex: A personal view.

    Journal of neurobiology·1999
    Same author

    Recordings from the striate cortex in awake behaving animals.

    Advances in neurology·1998
    Same author

    Early exploration of the visual cortex.

    Neuron·1998
    Same journal

    Diving exposure and pulmonary stress.

    The Journal of physiology·2026
    Same journal

    Systems modelling of mitochondrial dynamics in different exercise regimes.

    The Journal of physiology·2026
    Same journal

    Central leptin resistance precedes obesity and drives early endocrine dysfunction.

    The Journal of physiology·2026
    Same journal

    Decoding the molecular memory of obesity using machine learning and microRNA dynamics.

    The Journal of physiology·2026
    Same journal

    Kinematic-calcium loops unravel impaired excitation-contraction coupling in MELAS-affected cardioids.

    The Journal of physiology·2026
    Same journal

    hERG1 channels and potential therapeutics for long QT syndrome.

    The Journal of physiology·2026
    See all related articles

    Area of Science:

    • Neuroscience
    • Ophthalmology
    • Genetics

    Background:

    • Siamese cats possess a unique anatomical abnormality in their lateral geniculate body.
    • Aberrant retinal fiber crossing at the chiasm leads to incorrect hemispheric projection.
    • This results in the ipsilateral visual field being represented by the contralateral eye.

    Purpose of the Study:

    • To investigate the physiological consequences of aberrant visual projections in Siamese cats.
    • To examine the impact on the lateral geniculate body and visual cortex.
    • To understand the developmental mechanisms underlying these visual pathway anomalies.

    Main Methods:

    • Single-cell recordings were performed in the lateral geniculate body and visual cortex of Siamese cats.
    • Anatomical studies were referenced to confirm fiber projections.

    Related Experiment Videos

  • Comparisons were made with normal cats and cats raised with visual deprivation.

    • Main Results:

    • Confirmed aberrant projections in the lateral geniculate body, with ipsilateral visual fields represented by the contralateral eye.
    • Identified a systematic representation of the ipsilateral visual field within the visual cortex (areas 17 and 18).
    • Observed that receptive fields in the aberrant cortical representation were generally larger than normal and showed potential for binocular-like cell activity.

    Conclusions:

    • The aberrant visual pathway in Siamese cats leads to a unique representation of the visual field in the brain.
    • Developmental mechanisms for visual pathway formation appear to involve competing factors and topographic organization rather than strict cell-to-cell specificity.
    • Siamese cat visual anomalies offer a valuable model for studying nervous system development.