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Snake neurotoxins: effect of disulfide reduction on interaction with electroplax
Science (New York, N.Y.)
|December 17, 1971
Abstract:
Reduction of disulfide bonds of cobra neurotoxin by dithiothreitol results in decreased activity on the electroplax preparation. Activity is restored completely after reoxidation by 3,3'-dithiobis[6-nitrobenzoic acid]. Reduction of the disulfide bonds in the vicinity of the receptor does not decrease the effect of cobrotoxin.