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[Blood hormones in chronic ischemic heart disease and acute myocardial infarct]
Insights
Hormonal imbalances, including elevated pituitary hormones (ACTH, TTH, STH), are evident in chronic ischemic heart disease (CIHD) but not myocardial infarction (MI). Thyroid function is diminished in CIHD patients, potentially advancing atherosclerosis.
Area of Science:
- Endocrinology
- Cardiology
- Internal Medicine
Background:
- Chronic ischemic heart disease (CIHD) and myocardial infarction (MI) are significant cardiovascular conditions.
- Hormonal dysregulation may play a role in the pathophysiology of these diseases.
Purpose of the Study:
- To investigate the activity of specific blood hormones in patients with CIHD and MI compared to healthy individuals.
- To explore the relationship between pituitary and thyroid hormone levels and cardiovascular disease.
Main Methods:
- Radioimmune analysis was employed to measure hormone levels.
- Study included 58 CIHD patients, 60 MI patients, and 24 healthy controls.
Main Results:
- Patients with CIHD exhibited increased levels of pituitary hormones: adrenocorticotropic hormone (ACTH), thyrotropin (TTH), and somatotropin (STH).
- FSH and LH levels showed no significant changes in CIHD patients.
- Thyroid activity was diminished in CIHD patients, characterized by reduced thyroxine production despite high TTH.
- Hormone levels in MI patients did not significantly differ from the control group.
Conclusions:
- Observed hormonal shifts in CIHD suggest hypothalamo-hypophyseal dysfunction and altered coordinated system activity.
- Diminished thyroid function in CIHD, despite elevated TTH, indicates impaired thyroxine production.
- These hormonal changes may contribute to the progression of atherosclerosis and myocardial metabolism alterations in CIHD.
Abstract:
The activity of some blood hormones was determined by radioimmune analysis in 58 patients with chronic ischemic heart disease (CIHD), 60 patients with myocardial infarction (MI) and in 24 practically healthy individuals. Increased activity of pituitary hormones (ACTH and TTH) with simultaneous increase in the blood STH content in the absence of essential changes in the FSH and LH content was established. These shifts in the production of pituitary hormones are evidently due both to disorders in the hypothalamo-hypophyseal area and to changes in the activity of systems coordinated to the pituitary gland in patients with CIHD. In patients with MI the activity of these hormones in blood does not differ from that in the control group. In patients with CIHD, the activity of the thyroid is diminished due to a decrease in its thyroxin-producing ability against the background of high activity of the pituitary thyreotropic function. The discussed shifts in the activity of some hormones in CIND and MI are conducive to the advancement of atherosclerosis and changes in myocardial metabolism.