Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Morphologic observations on experimental corneal vascularization in the rat.

J S McCracken, P C Burger, G K Klintworth

    Laboratory Investigation; a Journal of Technical Methods and Pathology
    |December 1, 1979
    PubMed
    Summary

    Early corneal vascularization involves acute inflammation and rapid cell replication. New blood vessels sprout within 33 hours after injury, highlighting inflammation

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Progressive multifocal leukoencephalopathy in a patient without immunodeficiency.

    Neurology·2011
    Same author

    SAXS models of TGFBIp reveal a trimeric structure and show that the overall shape is not affected by the Arg124His mutation.

    Journal of molecular biology·2011
    Same author

    [The IC3D classification of the corneal dystrophies].

    Klinische Monatsblatter fur Augenheilkunde·2011
    Same author

    Rubella in the Newborn.

    British medical journal·2010
    Same author

    Paratentorial Grooving of Human Brains with Particular Reference to Transtentorial Herniation and the Pathogenesis of Secondary Brain-stem Hemorrhages.

    The American journal of pathology·2009
    Same author

    Diagnostic and prognostic value of glycosyltransferase mRNA in glioblastoma multiforme patients.

    Neuropathology and applied neurobiology·2006

    Area of Science:

    • Ophthalmology
    • Vascular Biology
    • Cell Biology

    Background:

    • Corneal vascularization is a pathological process.
    • Understanding its early stages is crucial for developing treatments.

    Purpose of the Study:

    • To investigate the early morphologic events of corneal vascularization.
    • To identify the cellular mechanisms driving neovascularization in the cornea.

    Main Methods:

    • Light and electron microscopy were used.
    • Rat corneas were injured using silver nitrate cautery.
    • The progression of vascular changes was observed over time.

    Main Results:

    • Acute inflammation, characterized by vascular dilation and leukocyte diapedesis, occurred within 6 hours.

    Related Experiment Videos

  • Vascular endothelial cells and pericytes showed signs of mitotic activity at 24 hours.
  • New blood vessel sprouts emerged by 33 hours post-injury.

    • Conclusions:

    • Acute inflammation is closely associated with corneal vascularization.
    • Vascular endothelial cell replication is an early event in this process.
    • This model provides insights into the initial stages of neovascularization.