Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Hemoglobin solution and the oxyhemoglobin dissociation curve.

A G Greenburg, C Elia, B Levine

    The Journal of Trauma
    |November 1, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Multi-site feasibility of a web-based and telephone navigation intervention to connect lung cancer caregivers in community oncology settings with resources: Protocol for the WF-2301CD Caregiver Oncology Needs Evaluation Tool (CONNECT) trial.

    Contemporary clinical trials·2026
    Same author

    Sleep selectively and durably enhances memory for the sequence of real-world experiences.

    Nature human behaviour·2025
    Same author

    Advancing youth tobacco surveillance with novel methods.

    Health education research·2024
    Same author

    Associations between air pollutants and blood pressure in an ethnically diverse cohort of adolescents in London, England.

    PloS one·2023
    Same author

    Air pollution and trajectories of adolescent conduct problems: the roles of ethnicity and racism; evidence from the DASH longitudinal study.

    Social psychiatry and psychiatric epidemiology·2021
    Same author

    Neutrophil gelatinase-associated lipocalin is a biomarker of acute-on-chronic liver failure and prognosis in cirrhosis.

    Journal of hepatology·2016
    Same journal

    Article.

    The Journal of trauma·2014
    Same journal

    Article.

    The Journal of trauma·2014
    Same journal

    Program schedule for the sixty-fifth annual meeting of the american association for the surgery of trauma.

    The Journal of trauma·2014
    Same journal

    Letters to the editor.

    The Journal of trauma·2014
    Same journal

    Posttraumatic brachial plexitis.

    The Journal of trauma·2011
    Same journal

    Incidental findings in focused assessment with sonography for trauma in hemodynamically stable blunt trauma patients: speaking about cost to benefit.

    The Journal of trauma·2011
    See all related articles

    Stroma-free hemoglobin solution shifts the oxyhemoglobin curve left, unlike Ringer's lactate. This finding is crucial for understanding hemodynamic responses in acute anemia.

    Area of Science:

    • Biochemistry
    • Physiology
    • Anesthesiology

    Background:

    • The oxyhemoglobin dissociation curve (ODC) describes oxygen release to tissues.
    • Hemoglobin-based oxygen carriers (HBOCs) are investigated for blood replacement.
    • Factors like pH and 2,3-diphosphoglycerate (2,3-DPG) influence the ODC.

    Purpose of the Study:

    • To determine the ODC of stroma-free hemoglobin solution.
    • To investigate the influence of pH and 2,3-DPG on this ODC.
    • To compare the effects of hemoglobin solution and Ringer's lactate in simulated acute volume replacement.

    Main Methods:

    • In vitro dilution experiments using whole blood.
    • Mixing whole blood with stroma-free hemoglobin solution or Ringer's lactate up to 50%.

    Related Experiment Videos

  • Analysis of oxyhemoglobin dissociation curve shifts.

    • Main Results:

    • Stroma-free hemoglobin solution exhibits a left-shifted ODC.
    • The left shift is responsive to pH changes but not to 2,3-DPG.
    • Hemoglobin solution caused a left shift in the ODC upon dilution, while Ringer's lactate did not.

    Conclusions:

    • Stroma-free hemoglobin solution alters oxygen-hemoglobin binding characteristics.
    • The observed ODC shift has implications for hemodynamic compensation in acute normovolemic anemia.
    • Understanding these effects is vital for the clinical application of HBOCs.