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Senile pulmonary amyloidosis.

W P Kunze

    Pathology, Research and Practice
    |August 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Pulmonary amyloidosis, a lung condition, increases significantly with age, affecting over 20% of individuals 85 and older. This age-related lung disease may stem from immune system changes and genetics.

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    Area of Science:

    • Gerontology
    • Pathology
    • Immunology

    Background:

    • Amyloidosis is a condition characterized by the buildup of abnormal proteins (amyloid) in organs.
    • Senile amyloidosis, particularly in the lungs, is increasingly recognized in aging populations.

    Purpose of the Study:

    • To investigate the prevalence and patterns of pulmonary amyloid deposits in individuals aged 80 years and over.
    • To explore the relationship between different forms of pulmonary amyloidosis and age.

    Main Methods:

    • Analysis of lung tissue from 340 necropsies of individuals aged 80+.
    • Utilized a sensitive fluorescence technique to detect pulmonary amyloid deposits.

    Main Results:

    • Pulmonary amyloidosis incidence was approximately 2% in those under 80, rising to nearly 10% (80-84 years) and over 20% (85+ years).

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  • Vascular and alveolar-septal amyloidosis occurred slightly more frequently than the pure septal form.
  • Different modes of pulmonary amyloidosis deposition were observed in distinct age groups.

    • Conclusions:

    • Pulmonary amyloidosis prevalence significantly increases with advanced age.
    • The findings suggest a link between age-related immunological disturbances and genetically determined factors in the pathogenesis of pulmonary amyloidosis.