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Candicidin: physiologic effect on prostate.

A Sporer, S Cohen, M H Kamat

    Urology
    |September 1, 1975
    PubMed
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    Candicidin therapy significantly improved benign prostatic hypertrophy symptoms in most patients. Histologic analysis revealed beneficial changes in prostate tissue composition without altering hormone levels.

    Area of Science:

    • Urology
    • Pharmacology
    • Histopathology

    Background:

    • Benign prostatic hypertrophy (BPH) is a common condition in aging men.
    • Current BPH treatments have varying efficacy and side effect profiles.
    • Novel therapeutic agents are needed for effective BPH management.

    Purpose of the Study:

    • To evaluate the clinical efficacy and histologic effects of candicidin in treating benign prostatic hypertrophy.
    • To assess the impact of candicidin therapy on hormonal levels in patients with BPH.

    Main Methods:

    • A double-blind, placebo-controlled study was conducted.
    • Patients with BPH received either candicidin or a placebo.
    • Clinical symptom improvement was assessed, and prostate tissue was reviewed histologically.

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  • Urinary and serum hormone levels were monitored.

    • Main Results:

    • 78.1% of patients receiving candicidin showed clinical improvement versus 10% in the placebo group.
    • Histologic examination revealed increased stroma, less active epithelium, and more cysts in candicidin-treated prostates.
    • Hormonal levels (testosterone, ketosteroids, corticosteroids, FSH) remained within normal ranges during candicidin therapy.

    Conclusions:

    • Candicidin therapy demonstrates significant clinical efficacy in improving BPH symptoms.
    • Histologic changes suggest a potential mechanism of action involving stromal-epithelial modulation.
    • Candicidin therapy appears safe regarding hormonal balance in BPH patients.