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Characterization of 3-O-methylmannose from Coccidioides immitis
Infection and Immunity
|November 1, 1971
Summary
Researchers identified 3-O-methylmannose from Coccidioides immitis. Gas chromatography confirmed its identity by comparing derivatives with synthetic 3-O-methylmannose, showing identical behavior.
Area of Science:
- Mycology
- Carbohydrate Chemistry
Background:
- Coccidioides immitis is a fungus.
- Understanding fungal metabolites is crucial for mycology and medicine.
Purpose of the Study:
- To characterize 3-O-methylmannose isolated from Coccidioides immitis.
- To confirm the identity of the naturally occurring sugar.
Main Methods:
- Isolation of 3-O-methylmannose from Coccidioides immitis.
- Preparation of three distinct derivatives of the isolated sugar.
- Gas chromatographic analysis of the derivatives.
- Comparison with derivatives of synthetic 3-O-methylmannose.
Main Results:
- The gas chromatographic behavior of three derivatives from the natural 3-O-methylmannose was identical to those of synthetic 3-O-methylmannose.
- This indicates the structural identity between the isolated and synthetic compounds.
Conclusions:
- The compound isolated from Coccidioides immitis is confirmed to be 3-O-methylmannose.
- This characterization provides a reference for future studies on Coccidioides immitis metabolites.