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Updated: Jul 10, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
Published on: February 27, 2014
Mechanism of fat malabsorption in rats infected with Nippostrongylus brasiliensis
Abstract:
Long-chain fatty acid absorption in rats with a jejunal lesion similar to that which is found in adult coeliac disease has been studied. Neither changes in the solubility of the fatty acid in the intestinal lumen nor histological abnormalities of the villous epithelium accounted for the malabsorptive state. Evidence was obtained from studies in vivo of a disturbance in the intramucosal esterification of long-chain fatty acid. Assay of the activity of the microsomal enzymes responsible for the conversion of fatty acid to triglyceride revealed that this pathway was defective in the parasitized animals.

