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Microglioma and/or reticulosarcoma of the nervous system
Abstract:
49 microgliomas of nervous parenchyma were studied, all of them with aniline techniques in part of the material embedded in paraffin, and the rest with Del Rio Hortega-Polak's technique in frozen sections. It is considered that the microglia is the representative of the R.E.S. in the nervous tissue, and is characterised by its cytoplasmic argentophilia. The existence of a non-argentophilic primitive reticular cell is denied, and it is maintained that microglioma and reticulosarcoma are synonymous thus refuting the concept of the existence of a reticulosarcoma consisting of non-argentophilic cells and a microglioma consisting of argentophilic cells, as different neoplasms.
Insights
This study investigates 49 nervous system tumors, concluding that microgliomas and reticulosarcomas are the same type of neoplasm. Microglia, the nervous system
Area of Science:
- Neuro-oncology
- Nervous System Pathology
- Cellular Biology
Background:
- Microglia are considered the reticuloendothelial system (RES) representatives in nervous tissue.
- Microglia are characterized by cytoplasmic argentophilia.
- Previous classifications distinguished neoplasms based on argentophilia.
Purpose of the Study:
- To clarify the relationship between microglioma and reticulosarcoma.
- To determine if argentophilia is a defining characteristic of these nervous tissue neoplasms.
- To refute the concept of distinct reticulosarcoma and microglioma entities.
Main Methods:
- Histological examination of 49 nervous parenchyma microgliomas.
- Application of aniline techniques on paraffin-embedded tissues.
- Application of Del Rio Hortega-Polak's technique on frozen sections.
Main Results:
- Argentophilia was observed as a characteristic of microglia.
- The study denied the existence of a non-argentophilic primitive reticular cell.
- Microglioma and reticulosarcoma were found to be synonymous.
Conclusions:
- Microglioma and reticulosarcoma are not distinct neoplasms.
- The concept of separate argentophilic microglioma and non-argentophilic reticulosarcoma is refuted.
- All studied neoplasms represent the same entity within nervous tissue.
