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Related Experiment Videos

On finding striated muscle in the brain.

S F Hoffman, L B Rorke

    Journal of Neurology, Neurosurgery, and Psychiatry
    |December 1, 1971
    PubMed
    Summary

    Striated muscle, typically found in the brain's protective layers (leptomeninges), is extremely rare. This study discusses its presence in an infant with trisomy 13-15 and congenital anomalies, exploring embryological origins.

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    Area of Science:

    • Neuropathology
    • Developmental Biology
    • Genetics

    Background:

    • Striated muscle is not a normal component of the leptomeninges.
    • Congenital anomalies can arise from complex genetic and developmental disruptions.
    • The presence of heterotopic tissues requires investigation into their embryological origins.

    Purpose of the Study:

    • To report an extremely rare finding of well-developed striated muscle in the leptomeninges.
    • To explore the potential embryological basis for this anomaly.
    • To discuss the implications for understanding central nervous system tumors with striated muscle components.

    Main Methods:

    • Histopathological examination of the leptomeninges and brain.
    • Correlation of neuropathological findings with genetic data (13-15 trisomy).
    • Review of embryological development and relevant literature.

    Main Results:

    • Well-developed striated muscle was identified within the leptomeninges of a 2-day-old infant.
    • The infant presented with 13-15 trisomy and multiple congenital anomalies.
    • Cerebral anomalies included arhinencephaly, minor sulcal abnormalities, and cerebellar dysplasias.

    Conclusions:

    • The presence of leptomeningeal striated muscle is an exceptionally rare finding.
    • An embryological explanation involving developmental field defects is proposed.
    • This finding may offer insights into the pathogenesis of central nervous system tumors containing striated muscle.

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