[Changes in lysozyme activity in the blood and organs of white rats exposed to cyclophosphane]

The lysozyme activity was estimated in the tissue and organs of white non-inbred rats. Cyclophosphane was injected trice intramuscularly in a single dose of 40 mg/kg of weight with a 4-day interval. The lysozyme activity was studied by a diffusion method in agar. The level of the enzyme was found to rise in the lung, blood serum, leucocytes and spleen. The most pronounced changes were noted 24 hours following its administration. Increased lysozyme activity may cause the enhanced digestive function of leucocytes and bactericidal properties of blood serum.