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Updated: Aug 2, 2026

Protective Efficacy and Pulmonary Immune Response Following Subcutaneous and Intranasal BCG Administration in Mice
Published on: September 19, 2016
[BCG-vaccination in the GDR--retrospective and prospective view (author's transl)]
Abstract:
A retrospective evaluation of BCG-vaccination from 1951--1977 shows the good effect on the number of TB-diseases especially among children. In former years with an annually infection-risk of 6--10% we found a big difference between TB-diseases in vaccinated and non-vaccinated persons. With the decreasing infections-risk (1977 0,05%) the absolute number and difference of diseases in vaccinated and non-vaccinated have become smaller and smaller. Nevertheless the decision was made to continue the BCG-vaccination of new-borns and pupils of 16 years in order to avoid also the last few cases of TB in children. The used BCG-vaccine produced in Jena/DDR has proved its immunogenic effect and caused very few complications. Till 1977 among nearly 10 millions of vaccinations only 68, mostly slight complications were registered.
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