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[Lung function studies with the bronchodilator terbutaline].

G Kaik, J Bonelli, G Hitzenberger

    Acta Medica Austriaca
    |January 1, 1979
    PubMed
    Summary
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    Terbutaline effectively reduces airway resistance in patients with chronic obstructive airways disease (COWD) and intrinsic asthma. This beta 2-adrenoceptor agonist demonstrated bronchodilator effects comparable to other treatments.

    Area of Science:

    • Pharmacology
    • Respiratory Medicine
    • Clinical Trials

    Background:

    • Chronic obstructive airways disease (COWD) and intrinsic asthma significantly impact respiratory function.
    • Bronchodilators are crucial for managing airway obstruction in these conditions.

    Purpose of the Study:

    • To evaluate the acute bronchodilator effect of terbutaline, a beta 2-adrenoceptor agonist.
    • To compare terbutaline's efficacy against other bronchodilators in COWD patients.
    • To assess the cardiovascular effects of terbutaline and related agonists in healthy volunteers.

    Main Methods:

    • Single-blind, cross-over study design.
    • Airway resistance measured using whole-body plethysmography.
    • Comparison of terbutaline with various bronchodilators, vagolytics, and xanthine derivatives.

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    Main Results:

    • Terbutaline demonstrated significant acute bronchodilator effects in out-patients with COWD and intrinsic asthma.
    • Comparisons showed terbutaline's efficacy relative to other marketed bronchodilators.
    • Studies in healthy volunteers assessed the impact on heart rate for terbutaline and other adrenoceptor agonists.

    Conclusions:

    • Terbutaline is an effective bronchodilator for managing chronic obstructive airways disease and intrinsic asthma.
    • The study provides comparative data on bronchodilator efficacy and cardiovascular effects.