Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Pre- and post-synaptic inhibition.

K Krnjević

    Advances in Experimental Medicine and Biology
    |January 1, 1979
    PubMed
    Summary
    This summary is machine-generated.

    Central inhibitory mechanisms, including GABA

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Genistein directly blocks glycine receptors of rat neurons freshly isolated from the ventral tegmental area.

    Neuropharmacology·2003
    Same author

    Decay of ethanol-induced suppression of glycine-activated current of ventral tegmental area neurons.

    Neuropharmacology·2002
    Same author

    Moderate hypoglycemia aggravates effects of hypoxia in hippocampal slices from diabetic rats.

    Neuroscience·2002
    Same author

    Ethanol inhibition of glycine-activated responses in neurons of ventral tegmental area of neonatal rats.

    Journal of neurophysiology·2001
    Same author

    Unlike 2-deoxy-D-glucose, 3-O-methyl-D-glucose does not induce long-term potentiation in rat hippocampal slices.

    Brain research·2001
    Same author

    Ethanol potentiation of glycine-induced responses in dissociated neurons of rat ventral tegmental area.

    The Journal of pharmacology and experimental therapeutics·2000

    Area of Science:

    • Neuroscience
    • Cellular Biology

    Background:

    • Central inhibitory mechanisms are crucial for regulating neuronal activity.
    • Inhibition operates via various neuronal circuits and at the cell membrane level.
    • Gamma-aminobutyric acid (GABA) is a key inhibitory neurotransmitter.

    Purpose of the Study:

    • To review the known mechanisms of central inhibition.
    • To explore the multifaceted roles of GABA in neuronal excitability and synaptic transmission.
    • To highlight potential areas for future research in GABAergic signaling.

    Main Methods:

    • Review of existing literature on central inhibitory mechanisms.
    • Analysis of cellular and molecular actions of GABA.
    • Discussion of GABA's effects on neuronal circuits and synaptic transmission.

    Related Experiment Videos

    Main Results:

    • Central inhibition is organized in feed-forward, feed-back, and disinhibition circuits.
    • Inhibition stabilizes neuronal activity postsynaptically by increasing chloride permeability.
    • Presynaptically, inhibition depresses transmitter release and may be modulated by electrogenic GABA transport and calcium influx.

    Conclusions:

    • While much is known about GABAergic inhibition, its full range of effects on neuronal excitability and synaptic transmission remains incompletely understood.
    • Further research may uncover novel mechanisms of GABA action.
    • GABAergic signaling plays a vital role in maintaining safe and finely graded neuronal activity.