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X-linked cleft palate.

R B Lowry

    Birth Defects Original Article Series
    |June 1, 1971
    PubMed
    Summary
    This summary is machine-generated.

    Cleft lip and palate prevalence differs between Indigenous and non-Indigenous populations in British Columbia. A family study suggests an X-linked recessive gene may cause isolated cleft palate in this group.

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    Area of Science:

    • Medical Genetics
    • Craniofacial Anomalies
    • Population Health

    Background:

    • Cleft lip with or without cleft palate (CL/P) exhibits varying prevalence across different ethnic groups.
    • Previous observations indicated differing frequencies of CL/P and isolated cleft palate (ICP) between Indigenous and non-Indigenous populations in British Columbia.

    Purpose of the Study:

    • To investigate the genetic basis of cleft palate in Indigenous populations of British Columbia.
    • To determine the prevalence and inheritance patterns of isolated cleft palate.

    Main Methods:

    • A descriptive study of clefting anomalies in British Columbia's Indigenous population.
    • Detailed family history and pedigree analysis of a family with multiple affected males.

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    Main Results:

    • Cleft lip with or without cleft palate is twice as frequent among Indigenous individuals compared to non-Indigenous individuals.
    • A specific family exhibited a pattern consistent with X-linked recessive inheritance for isolated cleft palate.
    • Isolated cleft palate is an extremely rare anomaly among the Indigenous people of British Columbia.

    Conclusions:

    • The genetic etiology of cleft palate may differ between Indigenous and non-Indigenous populations.
    • X-linked recessive inheritance is a potential cause for isolated cleft palate in certain families.
    • The rarity of isolated cleft palate underscores the need for further research into its specific causes in this population.