Morphologic approaches to the nosology of nervous system defects

Recent technologic advances demonstrate that the morphologic approach to the nosologic delineation of nervous system disorders is often inadequate. This tenet is exemplified by the hopeless confusion which neuropathology has imparted on the problem of amaurotic familial idiocy. The delineation of nosologic entities involving the nervous system may depart from morphologic studies but requires rigid confirmation by genetic and biochemical observations.