Related Experiment Videos
Folic acid hypersensitivity and fever: a case report
American Journal of Hospital Pharmacy
|November 1, 1979
Summary
Folic acid hypersensitivity can cause fever and rash in patients. Medical professionals should suspect this allergy if symptoms arise and cannot be otherwise explained.
Area of Science:
- Clinical Medicine
- Pharmacology
- Immunology
Background:
- Folic acid is a vital B vitamin crucial for numerous bodily functions.
- Hypersensitivity reactions to medications can range from mild to severe.
- Anephric patients may have altered drug metabolism and excretion.
Observation:
- A 36-year-old anephric patient developed pruritus upon daily folic acid administration.
- Upon re-administration, the patient experienced fever, generalized pain, chills, urticaria, and pruritus.
- Standard analgesics did not alleviate the symptoms, and leukocytosis was absent.
Findings:
- Intradermal challenge confirmed hypersensitivity to folic acid.
- The patient exhibited a clear allergic response to folic acid, presenting with fever and rash.
- Review of literature indicates previous reports of folic acid-induced hypersensitivity.
Implications:
- Clinicians should consider folic acid hypersensitivity in patients presenting with unexplained fever and rash.
- Prompt recognition and discontinuation of folic acid are crucial for managing hypersensitivity.
- This case highlights the importance of considering drug allergies in patients with complex medical histories, such as anephria.