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Ampicillin resistant Haemophilus parainfluenzae endocarditis
The American Journal of the Medical Sciences
|September 1, 1979
Abstract:
A case of Haemophilus parainfluenzae bacterial endocarditis is described. This is the first reported case of endocarditis caused by ampicillin resistant H parainfluenzae. Resistance was not mediated by a beta lactamase. Ampicillin therapy had not controlled the infection, but a four-week course of chloramphenicol was curative. Several general therapeutic points are discussed.
Insights
This case report details Haemophilus parainfluenzae endocarditis, the first caused by ampicillin-resistant strains not mediated by beta-lactamase. Chloramphenicol therapy proved curative after ampicillin failed.
Area of Science:
- Infectious Diseases
- Bacteriology
- Cardiology
Background:
- Bacterial endocarditis is a serious infection of the heart's inner lining.
- Haemophilus parainfluenzae is a Gram-negative bacterium that can cause various infections.
Observation:
- A patient presented with endocarditis caused by Haemophilus parainfluenzae.
- The causative organism exhibited resistance to ampicillin.
- This resistance mechanism was not attributed to beta-lactamase production.
Findings:
- This represents the first reported instance of endocarditis due to ampicillin-resistant Haemophilus parainfluenzae.
- Initial ampicillin treatment was ineffective in controlling the infection.
- A four-week course of chloramphenicol successfully eradicated the bacteria and resolved the endocarditis.
Implications:
- Highlights the emergence of antibiotic resistance in Haemophilus parainfluenzae.
- Suggests chloramphenicol as a potential therapeutic option for resistant cases.
- Underscores the importance of susceptibility testing in guiding endocarditis treatment.