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Related Experiment Videos

Methotrexate and fertility in men.

A El-Beheiry, E El-Mansy, N Kamel

    Archives of Andrology
    |January 1, 1979
    PubMed
    Summary

    Methotrexate, a folic acid antagonist, was studied in male psoriatic patients. The drug showed no adverse effects on male fertility, though long-term monitoring for teratogenic effects is recommended.

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    Area of Science:

    • Dermatology and Immunology
    • Reproductive Endocrinology
    • Pharmacology

    Background:

    • Psoriasis is a chronic inflammatory condition often treated with systemic medications.
    • Methotrexate is a folic acid antagonist commonly used for psoriasis.
    • Concerns exist regarding the potential impact of methotrexate on male reproductive health.

    Purpose of the Study:

    • To investigate the effects of methotrexate on male fertility in patients with psoriasis.
    • To assess semen parameters, testicular histology, and spermatogenic function.

    Main Methods:

    • Study included 26 male psoriatic patients undergoing methotrexate treatment.
    • Evaluated semen analysis.
    • Performed testicular histology and assessed spermatogenic function using radioactive phosphorus.

    Main Results:

    • Methotrexate did not demonstrate any unfavorable effects on male fertility parameters.
    • Semen quality and testicular histology remained unaffected.
    • Spermatogenic function showed no negative impact.

    Conclusions:

    • Methotrexate appears to have no deleterious effect on male fertility in psoriatic patients.
    • Further long-term follow-up is necessary to rule out potential teratogenic effects in offspring.
    • Continued monitoring of reproductive health in patients on methotrexate is warranted.

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