Non-organ-specific and tumour-specific antibodies in children with Wilms' tumour

Sera from groups of children with Wilms' tumour, with non-renal solid tumours, and from control children were studied by immunofluorescence and by absorption techniques. A high proportion of sera from both tumour groups contained non-organ-specific auto-antibodies. Three of the 45 sera in the Wilms' group and one of the 27 sera in the "other" solid tumour group contained antibody reacting with normal kidney cells. Only one of 45 sera in the Wilms' tumour group contained tumour-specific antibody.