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Effects of amiodarone on sinus node in man.
British Heart Journal
|November 1, 1979
Summary
Amiodarone prolonged corrected sinus node recovery time in patients, suggesting potential depression of atrial response conduction to the sinus node. This antiarrhythmic drug
Area of Science:
- Cardiology
- Electrophysiology
- Pharmacology
Background:
- Amiodarone is a widely used antiarrhythmic drug.
- Its effects on sinus node function require further elucidation.
Purpose of the Study:
- To investigate the electrophysiological effects of intravenous amiodarone on the human sinuatrial node.
Main Methods:
- Intravenous amiodarone (5 mg/kg) administered to 24 patients.
- Sinuatrial node function assessed via rapid atrial pacing and premature atrial stimulation.
Main Results:
- No significant change in sinus cycle length.
- Prolonged corrected sinus node recovery time observed.
- Prolongation of the non-reset zone and abolition of the plateau in some patients suggested depressed conduction.
Conclusions:
- Intravenous amiodarone can prolong corrected sinus node recovery time.
- Evidence suggests potential depression of atrial impulse conduction to the sinus node.