[Protein biosynthesis in the rat liver in natural fluctuations of the steroid background]

The results of the study of protein and RNA biosynthesis and inducation of glucose-6-phosphatase activity in the rat liver at natural (seasonal) fluctuations of the steroid background are presented. It is shown that the adrenal gland seasonal activation increases incorporation of precursors labeled (l14C-leucine and l14C-orotic acid) into total liver proteins and RNA and enhances glucose-6-phosphatase activity in the rat liver. The conclusion is drawn that the changes in the endogenous corticosteroid level have regulative significance for protein biosynthesis in the rat liver.