[Rosette formation in a cell population syngeneic transfer system from donors with an altered serotinin level]

The formation of primary immune response has been studied during transplantation to sublethally irradiated recipients of cells from different immunocompetent organs of non-immune intact donors as well as of those from animals injected serotonin. Considerable variations in the development of the immune reaction have been mainly discovered due to IgM-forming cells, both during the transfer of spleen cells alone and in combined injection of these cells with bone marrow and thymus cells from the same donors. The results obtained suggest a possible serotonine influence on variations in the ratio and migration of T and B cells in different organs and on T and B suppressor cells.