[Hematopoietic stem cell migration study in dogs]

The migration rate of stem hemopoietic cells (SHC) of the bone marrow was studied by two methods in experiments on 54 dogs. In the first case the dogs were irradiated with an absolute lethal dose (550 R) subtotally, shielding two knee-joints. Seven days after the first irradiation under inactivation of shielded parts with 2000 R dose the survival rate was 12.5% and after 14-day inactivation all the dogs survived. In the second case firstly both knee-joints were irradiated with 2000 R dose. All the animals died following subsequent subtotal irradiation of the areas previously irradiated with 550 R dose if the second irradiation was performed 7 days after the first one. Prolongation of the time intervals between irradiations up to 31 days lead to 20% survival of the animals. It was concluded that SHC migration in dogs is much lower than in mice.