Related Experiment Video
Updated: Aug 16, 2026

Improved Protocol for Chromatin Immunoprecipitation from Mouse Skeletal Muscle
Published on: November 7, 2017
[Cholinergic regulation of transcription in the liver]
Abstract:
The rate of the RNA synthesis in the rat liver was enhanced 6 hours after intramuscular administration to rats of acetylcholine, carbamylcholine or chlorosil at doses of 20, 1 and 2 mg/kg, respectively. At a dose of 0.025 mg/kg chlorosil failed to influence the transcription rate, but partially blocked its stimulation by carbamylcholine. Chlorosil and carbamylcholine did not change the RNA synthesis rate in isolated hepatocytic nuclei. It is suggested that the effect is mediated by their interaction with the cholinoreceptor or with the cell plasmatic membrane sites structurally associated with it.
Related Concept Videos
Cell Specific Gene Expression
Co-activators and Co-repressors
Master Transcription Regulators
Cholinergic Neurons: Neurotransmission
Cholinergic Receptors: Muscarinic
The subtypes M1, M3, and M5 couple with the Gq subunit and activate the phospholipase C (PLC) activity, mobilizing intracellular Ca2+. Activation...
Parasympathetic Signaling
The effects of...

