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Related Experiment Videos

Pregnancy in patients presenting with hyperprolactinaemia.

M O Thorner, C R Edwards, M Charlesworth

    British Medical Journal
    |September 29, 1979
    PubMed
    Summary

    Bromocriptine safely treats hyperprolactinemia, aiding conception and pregnancy. Pituitary irradiation before pregnancy prevents prolactinoma expansion, safeguarding vision in women with pituitary tumors.

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    Area of Science:

    • Endocrinology
    • Reproductive Medicine
    • Neurosurgery

    Background:

    • Hyperprolactinemia is a common endocrine disorder affecting fertility.
    • Prolactinomas, pituitary tumors causing hyperprolactinaemia, can expand during pregnancy.
    • Management of hyperprolactinemia and associated pituitary tumors during pregnancy requires careful consideration.

    Purpose of the Study:

    • To evaluate the safety and efficacy of bromocriptine in achieving pregnancy in hyperprolactinaemic patients.
    • To assess the outcomes of pregnancies in women with hyperprolactinemia, including rates of abortion, fetal abnormalities, and multiple births.
    • To determine the effectiveness of prophylactic pituitary irradiation in preventing pituitary tumor expansion during pregnancy.

    Main Methods:

    • Retrospective analysis of 92 pregnancies in 76 hyperprolactinaemic patients treated with bromocriptine.

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  • Review of pregnancy outcomes, including conception rates, spontaneous abortion, fetal abnormalities, and multiple pregnancies.
  • Assessment of pituitary tumor behavior during pregnancy in patients who received or did not receive pre-conception pituitary irradiation.

    • Main Results:

    • Bromocriptine treatment led to conception in half of the patients within three months.
    • No increased rates of spontaneous abortion, fetal abnormality, or multiple pregnancy were observed.
    • Pituitary irradiation before conception prevented tumor expansion and visual field defects in patients with large prolactinomas.

    Conclusions:

    • Bromocriptine is effective for achieving pregnancy in hyperprolactinaemic patients.
    • Pregnancy in hyperprolactinaemic women treated with bromocriptine is generally safe with normal outcomes.
    • Pre-conception pituitary irradiation is a safe and effective prophylactic measure against prolactinoma expansion during pregnancy.