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Related Experiment Videos

Acute bronchoconstriction caused by Beclovent and not Vanceril.

J Godin, J L Malo

    Clinical Allergy
    |November 1, 1979
    PubMed
    Summary
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    Asthma patients may experience acute wheezing from beclomethasone dipropionate aerosols. The reaction may be due to inactive ingredients in the inhaler device, not the medication itself.

    Area of Science:

    • Pulmonary Medicine
    • Allergy and Immunology
    • Pharmacology

    Background:

    • Asthma management often involves inhaled corticosteroids like beclomethasone dipropionate.
    • Patients rely on metered-dose inhalers for consistent medication delivery.
    • Identifying triggers for acute asthma exacerbations is crucial for effective treatment.

    Observation:

    • A 24-year-old asthmatic patient developed immediate wheezing post-inhalation of beclomethasone dipropionate (Beclovent).
    • Bronchial challenge tests confirmed bronchoconstriction with both the active beclomethasone aerosol and its placebo.
    • A different brand of beclomethasone aerosol (Vanceril) did not elicit a similar reaction.

    Findings:

    • The patient's acute bronchoconstriction was triggered by a beclomethasone dipropionate aerosol, but not by a different brand.

    Related Experiment Videos

  • The reaction occurred even with a placebo formulation lacking the active drug, suggesting an issue with inactive components.
  • The metering valve's rubber or plastic derivatives were implicated as potential causative agents.

    • Implications:

    • This case highlights potential hypersensitivity reactions to inactive ingredients in metered-dose inhalers.
    • Healthcare providers should consider device components as a possible cause of unexplained aerosol reactions.
    • Further investigation into excipients and device materials in respiratory inhalers is warranted.