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Cimetidine induced prolactin (PRL) release in thyroid disease
Clinical Endocrinology
|October 1, 1979
Summary
Cimetidine administration significantly increased prolactin (PRL) levels in all participants, regardless of thyroid status. This PRL release induced by cimetidine is independent of thyroid hormone levels.
Area of Science:
- Endocrinology
- Pharmacology
Background:
- Thyroid hormones influence the hypothalamic-pituitary-gonadal and thyroid axes.
- Cimetidine is known to affect hormone secretion.
Purpose of the Study:
- To investigate the effects of cimetidine on serum levels of prolactin (PRL), thyroid-stimulating hormone (TSH), luteinizing hormone (LH), and follicle-stimulating hormone (FSH).
- To determine if cimetidine-induced PRL release is dependent on thyroid hormone levels.
Main Methods:
- Acute intravenous administration of cimetidine.
- Measurement of serum PRL, TSH, LH, and FSH levels in healthy euthyroid, hypothyroid, and hyperthyroid patients.
- Analysis of hormone level changes at baseline and post-administration.
Main Results:
- Cimetidine administration caused a two to three-fold increase in serum PRL levels in all subjects (euthyroid, hypothyroid, and hyperthyroid).
- Peak PRL levels were observed 15 minutes post-administration.
- Cimetidine did not alter TSH levels in hypothyroid patients and had minimal effect on LH and FSH levels.
Conclusions:
- Cimetidine-induced PRL release is independent of thyroid hormone levels.
- The mechanism of cimetidine-induced PRL release differs from thyrotropin-releasing hormone (TRH)-mediated release.