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Methicillin-resistant staphylococci 1965-75.

F H Kayser

    Lancet (London, England)
    |October 4, 1975
    PubMed
    Summary
    This summary is machine-generated.

    Methicillin-resistant Staphylococcus aureus (MRSA) infections decreased significantly in Zurich hospitals after 1971. This decline in MRSA, a common cause of gram-positive infections, occurred despite antibiotic use, suggesting other factors influenced its prevalence.

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    Area of Science:

    • Medical Microbiology
    • Infectious Diseases
    • Hospital Epidemiology

    Background:

    • Methicillin resistance in Staphylococcus aureus (MRSA) posed a significant challenge for gram-positive infections in Zurich hospitals.
    • MRSA accounted for approximately 20% of staphylococcal disease cases up to 1971.

    Purpose of the Study:

    • To investigate the trends and potential factors influencing the prevalence of methicillin-resistant Staphylococcus aureus in the Zurich hospital setting.
    • To analyze the characteristics of isolated MRSA strains and their epidemiological patterns over time.

    Main Methods:

    • Retrospective analysis of Staphylococcus aureus cultures isolated from hospital patients between 1965 and 1975.
    • Phage-typing and antibiotyping to characterize methicillin-resistant isolates.

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  • Correlation of MRSA prevalence with antibiotic usage patterns.

    • Main Results:

    • A notable decrease in MRSA prevalence was observed starting in 1972, reaching a low of 3% by 1975.
    • Nearly 700 MRSA cultures isolated since 1965 shared common phage-typing (group-II lysis) and antibiotyping patterns, suggesting a common strain origin.
    • No significant correlation was found between the use of penicillinase-resistant beta-lactam antibiotics and the observed changes in MRSA frequency.

    Conclusions:

    • The observed fluctuations in MRSA prevalence in Zurich hospitals appear to be driven by factors other than the direct impact of penicillinase-resistant beta-lactam antibiotic usage.
    • The findings suggest that a long-standing strain of MRSA may be responsible for infections, with its prevalence influenced by unelucidated epidemiological dynamics.