Interstitiospinal action on forelimb, hindlimb, and back motoneurons

Responses of motoneurons supplying muscles of the forelimbs, hindlimbs, and back to stimulation of the interstitial nucleus of Cajal (INC) were recorded intracellularly in cats under chloralose anesthesia. Stimulation of the ipsilateral and contralateral INC evoked predominantly excitatory postsynaptic potentials in these motoneurons. Response latencies and properties of responses to multiple shock stimuli indicated that the responses were evoked by a di- or polysynaptic pathway. Stimulation of the anterior MLF (P2), which should have activated the entire interstitiospinal tract, but few reticulospinal or vestibulospinal fibers, evoked only polysynaptic responses. These results indicate that the INC does not establish direct synaptic connections with limb and back motoneurons.